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Dictyostelium as a model organism

 ​Members of the Huber lab are bolded
++  Trent University graduate student
+    Trent University undergraduate student
#    Equal contribution


Huber RJ, Kim WD++, Mathavarajah, S. (2021). Inhibiting neddylation with MLN4924 suppresses growth and delays multicellular development in Dictyostelium discoideum. Biomolecules 11(3), 482 plus supplementary data. Special Issue: Looking Back and Ahead: Emerging Concepts in Ubiquitin and UBLs. doi:10.3390/biom11030482​

Mathavarajah S, VanIderstine C, Dellaire G, Huber RJ. Cancer and the breakdown of multicellularity: What Dictyostelium discoideum, a social amoeba, can teach us. BioEssays 43(4), e2000156. doi:10.1002/bies.202000156
 
Huber RJ, Hughes SM, Liu W, Morgan A, Tuxworth RI, Russell C. (2020). The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866(9), 165614. doi:10.1016/j.bbadis.2019.165614
 
Aoki MM++, Emery RJN, Anjard C, Brunetti CR, Huber RJ. (2020). Cytokinins in Dictyostelia – A unique model for studying the functions of signaling agents from species to kingdoms. Frontiers in Cell and Developmental Biology 8, 511. doi:10.3389/fcell.2020.00511
 
Huber RJ. (2020). Molecular networking in the neuronal ceroid lipofuscinoses: Insights from mammalian models and the social amoeba Dictyostelium discoideum. Journal of Biomedical Science 27(1), 64. doi:10.1186/s12929-020-00653-y
 
O’Day DH#, Mathavarajah S+#, Myre MA#, Huber RJ#. (2020). Calmodulin-mediated events during the life cycle of the amoebozoan Dictyostelium discoideum. Biological Reviews of the Cambridge Philosophical Society 95(2), 472-490. doi:10.1111/brv.12573
 
McLaren MD++, Mathavarajah S+, Huber RJ. (2019). Recent insights into NCL protein function using the model organism Dictyostelium discoideum. Cells 8(2), 115. doi:10.3390/cells8020115​
 
Myre MA#, Huber RJ#, O’Day DH#. (2018). Functional Analysis of Proteins Involved in Neurodegeneration Using the Model Organism Dictyostelium: Alzheimer’s, Huntington’s and Batten Disease. Chapter 21, In: Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research, First Edition, Gerlai RT (Editor), Academic Press: Elsevier, San Diego, CA, pp. 491-518. ISBN: 9780128040782 (Invited).
 
Mathavarajah S+, Flores A+, Huber RJ. (2017). Dictyostelium discoideum: A model system for cell and developmental biology. Current Protocols Essential Laboratory Techniques 15, 14.1.1-14.1.19. doi:10.1002/cpet.15
 
Huber RJ, O’Day DH. (2017). Extracellular matrix dynamics and functions in the social amoeba Dictyostelium: A critical review. Biochimica et Biophysica Acta (BBA) - General Subjects 1861(1), 2971-2980. doi:10.1016/j.bbagen.2016.09
 
Huber RJ. (2016). Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis. Journal of Biomedical Science 23(1), 83. doi:10.1186/s12929-016-0301-0
 
Kovacs-Bogdan E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK. (2014). Reconstitution of the mitochondrial calcium uniporter in yeast. Proceedings of the National Academy of Sciences of the United States of America 111(24), 8985-8990 plus supplementary data. doi:10.1073/pnas.1400514111
 
Huber RJ. (2014). The cyclin-dependent kinase family in the social amoebozoan Dictyostelium discoideum. Cellular and Molecular Life Sciences 71(4), 629-639. doi:10.1007/s00018-013-1449-3
 
Huber RJ, O’Day DH. (2012). A matricellular protein and EGF-like repeat signalling in the social amoebozoan Dictyostelium discoideum. Cellular and Molecular Life Sciences 69(23), 3989–3997. doi:10.1007/s00018-012-1068-4
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