Huber lab

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​WELCOME TO THE HUBER LAB
AT TRENT UNIVERSITY

WHERE WE STUDY FUNDAMENTAL CELLULAR PROCESSES AND
​HOW THEY ARE IMPACTED IN HUMAN DISEASE

​News
​​March 2023
  • Our new paper in European Journal of Cell Biology summarizes important discoveries in Batten disease research using Dictyostelium discoideum as a model system. It is also Adam's first publication. Congratulations Adam! See Publications page for more details.
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October 2022
  • Our new paper in Frontiers in Genetics examines the effect of cln5 gene deletion on the transcriptome in Dictyostelium discoideum. See Publications page for more details.

September 2022
  • The Huber Lab welcomes Cassandra and Adam who will be completing undergraduate Honour's theses in the lab.
  • Will is currently at Harvard Medical School and Massachusetts General Hospital completing an internship in Dr. Susan Cotman's lab. You can read about Will's exciting experience here: https://www.trentu.ca/news/story/34087

August 2022
  • Will presented his work at the 2022 International Dictyostelium Conference in Scotland.
  • Awesome new YouTube video describing the Dictyostelium life cycle: https://www.youtube.com/watch?v=vlANF-v9lb0 

May 2022
  • Congrats to Elicia on publishing her MSc thesis in Frontiers in Cell and Developmental Biology. See Publications page for more details.

April 2022
  • Congrats to Will on securing a 3-year Canada Graduate Scholarship from NSERC!
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February 2022
  • New papers this month in BMC Neuroscience, Frontiers in Physiology, and Frontiers in Cell and Developmental Biology. See Publications page for more details.

January 2022
  • Our 2019 paper in Biomolecules has been awarded the Biomolecules 2021 Best Video Abstract Award!

November 2021
  • Congratulations Elicia on successfully defending your MSc thesis!

October 2021
  • Check out our new review in Disease Models & Mechanisms that discusses the role of altered protein secretion in Batten disease. See Publications page for more details.
  • Check out the Trent News story about Megan's International Dicty Award!
    • https://www.trentu.ca/news/story/31485​

September 2021
  • We welcome new graduate students Joshua Gray and Adam Remtulla and new undergrad Thomas Burnside into the lab! 

August 2021
  • Congrats to Megan on being awarded the 2021 International Dictyostelium Graduate Student Award. A well deserved accomplishment! 

May 2021
  • A total team effort from the Huber Lab! Check out our new paper in Frontiers in Cell and Developmental Biology entitled "Aberrant autophagy impacts growth and multicellular development in a Dictyostelium knockout model of CLN5 disease". See Publications page for more details.

April 2021
  • Congratulations to Elicia on being awarded a 2021 David and Joyce Woods Graduate Scholarship!

March 2021
  • Check out our new paper in Biomolecules that examines the effect of Pevonedistat (MLN4924) on Dictyostelium growth and development. Pevonedistat is currently being explored as a potential therapy for cancer, chronic liver diseases, and autoimmune diseases. See Publications page for more details.
  • Our article "The converging roles of Batten disease proteins in neurodegeneration and cancer" has been accepted for publication in iScience. See Publications page for more details.

February 2021
  • Our paper that provides a catalogue of calmodulin-binding proteins in Dictyostelium has been accepted for publication by International Journal of Molecular Sciences and will appear in the Special Issue: Calmodulin Binding Proteins. See Publications page for more details.

January 2021
  • Congrats to Will on a successful conversion to the Ph.D. program!

December 2020
  • Check out our new paper in BioEssays that describes how Dictyostelium can be used to gain insight into the pathways that regulate the breakdown of multicellularity in cancer. This is an exciting paper that was the result of a collaboration with the Dellaire Lab at Dalhousie University.​ See Publications page for more details.

November 2020
  • Kaitlyn Neuman, a Huber Lab alumnus, was recently featured in the Huntington Society of Canada's Newsletter "Horizon" (Issue 162 - Fall). Congratulations Kaitlyn! https://www.huntingtonsociety.ca/horizon/

October 2020
  • Rob is serving as a Guest Associate Editor for a Research Topic in Frontiers in Cell and Developmental Biology. Click the link for more information: https://www.frontiersin.org/research-topics/16964/dictyostelium-a-tractable-cell-and-developmental-model-in-biomedical-research

September 2020
  • Megan's 2019 paper in Biomolecules was recently recognized as an "Editor's Choice Article" by the Editors of the Journal: https://www.mdpi.com/2218-273X/9/11/702​. Congratulations Megan!
  • YouTube link: https://www.youtube.com/watch?v=sI6gYDWqxSU&feature=youtu.be

July 2020
  • Rob is serving as a Guest Editor for a Special Issue on Calmodulin Binding Proteins in the International Journal of Molecular Sciences. Click the link below for more details. Submission closes January 31, 2021.​https://www.mdpi.com/journal/ijms/special_issues/Calmodulin_Proteins

May 2020
  • Check out Megan's new paper in Frontiers in Cell and Developmental Biology that details the functions of cytokinins during the Dictyostelium life cycle. See Publications page for more details.
  • Congrats to Elicia and Will on securing Ontario Graduate Scholarships for 2020-2021. Also, congrats to Megan for receiving a highly prestigious NSERC CGS D. Well done everyone!

April 2020
  • Congratulations to Meagan on successfully defending her M.Sc. thesis! 
  • Rob's new paper entitled "Molecular networking in the neuronal ceroid lipofuscinoses: Insights from mammalian models and the social amoeba Dictyostelium discoideum" has been accepted for publication in Journal of Biomedical Science. See Publications page for more details.
March 2020
  • To learn more about how calmodulin and calmodulin-binding proteins regulate the Dictyostelium life cycle, check out our new review in Biological Reviews. ​See Publications page for more details.
  • Check out our new paper in Cellular Signalling that reports the localization and function of the Dictyostelium homolog of MFSD8. Mutations in MFSD8 are associated with CLN7 disease (a subtype of Batten disease). See Publications page for more details.
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November 2019
  • Rob is excited to announce that the encyclopedia of using cellular models to study Batten disease has been accepted for publication in BBA Molecular Basis of Disease. See Publications page for more details.
  • Congratulations Megan on your recently accepted paper in Biomolecules.

August 2019
  • The Huber lab is currently recruiting graduate students and a postdoc for January 2020. Interested applicants should email Dr. Huber directly (roberthuber@trentu.ca) with an updated CV, transcript, and statement of interest. 
  • Congratulations to Rob on winning the 2019 Dictyostelium Junior Faculty Award, which was presented at the 2019 International Dictyostelium Conference!
  • Meagan, Megan, Elicia and Rob presented their work at the 2019 International Dictyostelium meeting.

July 2019
  • The Huber lab is excited to announce that our application to the CIHR Project Grant competition was approved for 5 years of funding! We will post new graduate student and postdoc positions sometime in the near future. 

May 2019
  • The Huber lab is excited to join the Molecules, Cells & Systems Research Group at Trent University. You can read more about this new initiative here: https://www.trentu.ca/researchinnovation/trent-research-matters/centres-and-institutes
  • We are happy to welcome Evan Schuett into the lab as a graduate student.
  • Congratulations to Will and Ali on receiving NSERC USRAs.

April 2019
  • Congratulations to Elicia on receiving the Zobel Conference Travel Award. Elicia will be presenting her exciting work on Mfsd8 function in Dictyostelium at the Dicty 2019 meeting!
  • Congratulations to Will on receiving an NSERC CGS M! Will will be starting his M.Sc. in the Huber lab in September. 

February 2019
  • Check out our new paper in Cellular Signalling that explores the mechanisms underlying Cln3 function in Dictyostelium. See Publications page for details.

January 2019
  • Read our latest paper to learn how Dictyostelium is being used to study the functions of proteins linked to Batten disease. See Publications page for more details.

October 2018
  • ​Check out our new paper that sheds light on the potential involvement of calmodulin in Batten disease. See Publications page for more details.
  • Congratulations to Elicia and Will on receiving their 2018 Chemistry Awards!

August 2018
  • Congrats to Meagan on receiving a travel award from the International Society for Neurochemistry to attend the NCL 2018 meeting in London, UK!
  • Our paper entitled "Cln3 function is linked to osmoregulation in a Dictyostelium model of Batten disease" has been accepted for publication in BBA Molecular Basis of Disease! See Publications page for more details.

July 2018
  • Trent University News wrote a nice story about our recent funding from the Banting Research Foundation www.trentu.ca/news/story/21869 
  • Hot off the press! Our new paper entitled "Secretion and function of Cln5 during the early stages of Dictyostelium development" has been accepted for publication in BBA Molecular Cell Research. See Publications page for more details.
  • We are excited to welcome Elicia Yap and William Kim into the lab. Elicia and William will be working on their Biochemistry and Molecular Biology research theses during the 2018-2019 academic year.

June 2018
  • We received some great news today. Our grant entitled "Using the social amoeba Dictyostelium discoideum to study neuronal ceroid lipofuscinosis" has been funded by the Banting Research Foundation. We would like to thank the Foundation for their generous support of our work.

March 2018
  • Congratulations to Saby on placing 2nd in Trent University's 4th Annual Three Minute Paper (3MP) Competition. Saby did a great job describing how we use Dictyostelium to study Batten disease. You can read about the competition here: http://www.trentu.ca/newsevents/newsDetail.php?newsId=20 
  • Congratulations to Saby on being awarded an NSERC Undergraduate Student Research Award for Summer 2018

November 2017
  • Trent University News wrote a nice story on our recent paper. Check it out here: http://www.trentu.ca/newsevents/newsDetail.php?newsId=19807
  • Our paper on Cln5 localization and function in Dictyostelium has been accepted for publication in Cellular Signalling. See Publications page for more details.

September 2017
  • We are excited to welcome Meagan McLaren into the lab as a M.Sc. student!

July 2017
  • Check out our recent paper entitled "Dictyostelium discoideum: A model system for cell and developmental biology" which will appear in Current Protocols Essential Laboratory Techniques. See Publications page for more details.
  • To learn more about how we can use Dictyostelium to study neurodegeneration, check out our recent book chapter entitled "Functional Analysis of Proteins Involved in Neurodegeneration Using the Model Organism Dictyostelium: Alzheimer’s, Huntington’s and Batten Disease" which will appear in the Second Edition of Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research. See Publications page for more details.

May 2017
  • Rob and Saby had a great time at the Canadian Society for Molecular Biosciences Annual Meeting where they presented their work on using Dictyostelium as a model system for studying NCL.

March 2017
  • Our paper entitled "Loss of Cln3 impacts protein secretion in the social amoeba Dictyostelium" has been accepted for publication in Cellular Signalling. See Publications page for more details.
  • We would like to acknowledge the generous support provided by the Canada Foundation for Innovation through the John R. Evans Leaders Fund. See Media page for more details.

January 2017
  • Congratulations to Saby on being awarded an NSERC Undergraduate Student Research Award for Summer 2017

December 2016
  • Check out our recently published papers in Cell Adhesion & Migration, Biochimica et Biophysica Acta, and Journal of Biomedical Science. See Publications page for more details.

November 2016
  • Profile on Dr. Huber's research program at Trent University: https://www.trentu.ca/newsevents/newsDetail.php?newsId=16991
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